acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats

نویسندگان

hossein hosseinzadeh pharmaceutical sciences research center, department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir. iran.

saied sadeghi shakib department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir. iran.

abbas khadem sameni javadolaemeh cardiac hospital, mashhad, i. r. iran.

elahe taghiabadi department of pharmacodynamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, ir. iran.

چکیده

the acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. for subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. the intraperitoneal ld50 values of safranal were 1.48 ml/kg in male mice, 1.88 ml/kg in female mice and 1.50 ml/kg in male rats. oral ld50 values were 21.42 ml/kg in male mice, 11.42 ml/kg in female mice and 5.53 ml/kg in male rats. for subacute toxicity, safranal was administered orally to male rats once daily for 21 days. in hematological tests, a significant decrease in rbc counts, hematocrit, hemoglobin and platelets were observed. safranal decreased cholesterol, triglyceride and alkalin phosphatase. lactate dehydrogenase and serum urea nitrogen were increased by safranal. histological studies indicated that safranal did not have any toxic effect on the heart, liver and spleen. however, pathological changes were seen in the kidney and lung. according to ld50 values, safranal was low-toxic in acute intraperitoneal route and practically non-toxic in acute oral administration in both mice and rats. in subacute toxicity, safranal changed some hematological and biochemical parameters.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Acute and Subacute Toxicity of Safranal, a Constituent of Saffron, in Mice and Rats

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

متن کامل

Acute and Subacute Toxicity of Safranal, a Constituent of Saffron, in Mice and Rats

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

متن کامل

Acute and Subacute Toxicity of Safranal, a Constituent of Saffron, in Mice and Rats

The acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. For subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. The intraperitoneal LD50 values of safranal were 1.48 mL/kg in male mice, 1.88 mL/kg in female mice and 1.50 mL/kg in male rats. Oral LD50 values were ...

متن کامل

Saffron Reduced Toxic Effects of its Constituent, Safranal, in Acute and Subacute Toxicities in Rats

BACKGROUND Saffron and its constituents are widely used around the world as a spice and medicinal plant. Different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. So, efforts have been made to find the best and most valuable tools to reduce their adverse effects. OBJECTIVES According to Iranian traditional medicine (ITM), it is believ...

متن کامل

saffron reduced toxic effects of its constituent, safranal, in acute and subacute toxicities in rats

conclusions: the co-administration of saffron aqueous extract and safranal reduced toxic effects of safranal in acute and sub-acute toxicities. background: saffron and its constituents are widely used around the world as a spice and medicinal plant. different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. so, efforts have been made to ...

متن کامل

Safranal, a Saffron Constituent, Attenuates Retinal Degeneration in P23H Rats

Saffron, an extract from Crocus sativus, has been largely used in traditional medicine for its antiapoptotic and anticarcinogenic properties. In this work, we investigate the effects of safranal, a component of saffron stigmas, in attenuating retinal degeneration in the P23H rat model of autosomal dominant retinitis pigmentosa. We demonstrate that administration of safranal to homozygous P23H l...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۲، شماره ۱، صفحات ۹۳-۹۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023